The line, which serves the Belair-Edison area, is the oldest shuttle-like bus route in Baltimore, dating back to the 1940s.

It operates in a similar circular fashion from its lone layover point, the intersection of Erdman Avenue and Belair Road.

[2][3] It became counterclockwise only in 1992 in order to save costs and simplify service, then operating consistently every 20 minutes during all its hours.

On April 2, 2007, Route 50 started to provide service on selected trips to the Claremont Senior Home.

The branch to the Claremont Senior Home was ended, since the building was razed for the Orchard Ridge development.