Route 5 is a National Road in Bolivia.

The road is 898 km long and traverses the Bolivian Altiplano from northeast to southwest, from the Cordillera Oriental.

The road crosses the departments of Santa Cruz, Cochabamba, Chuquisaca, and Potosí.

[1] Route 5 begins in the north-east as a turnoff from Route 7 at La Palizada and ends in the south-west at a village of Hito LX on the Chilean border.

Route 5 has been declared part of the Bolivian National Road "Red Vial Fundamental" by Decree 25.134 of 31 August 1998.