National Route 5 (in Spanish, Ruta Nacional Número 5 "Gral.

Bernardino Caballero", or simply Ruta Quinta) is a highway in northern Paraguay, it runs from Fortín Pilcomayo to Pedro Juan Caballero.

It crosses 3 departments, Presidente Hayes, Concepcion, and Amambay.

The following table shows the distances traversed by National Route 5 in each different department, and important cities that it passes by (or near).