Rouvroy-en-Santerre (French pronunciation: [ʁuvʁwa ɑ̃ sɑ̃tɛʁ], literally Rouvroy in Santerre) is a commune in the Somme department in Hauts-de-France in northern France.

The commune is situated some 20 miles (32 km) southeast of Amiens, at the junction of the D161 and D131 roads.

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