Vaughan was a staunch royalist follower of Charles I during the English Civil War.
After his release from prison, Vaughan focused on rebuilding his finance and exchanging literary works with local poets.
Vaughan's translations are of a generally high standard, of works largely Calvinist in content but within a royalist and Anglican context.
After the foundation of the National Library of Wales, the papers were filed in the Brogyntyn Collection of the Department of Manuscripts at Aberystwyth.
Vaughan's land-holdings passed to several generations of his descendants but ultimately merged with those of Syr Watkin Williams Wyn circa 1740