This is accomplished through the action of the viral Nonstructural Protein NSP3 which specifically binds the 3' consensus sequence of viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G I.

In the carboxy terminus, at least five zinc finger motifs are observed, further suggesting the capacity of RoXaN to bind other proteins or nucleic acids.

Between these two regions exists a paxillin leucine-aspartate repeat (LD) motif which is involved in protein–protein interactions.

[6] RoXaN is capable of interacting with NSP3 in vivo and during rotavirus infection.

[7] This article on a gene on human chromosome 22 is a stub.