It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins.

It is found in tandem arrays of 3–16 motifs,[1] which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes.

The structure solved by X-ray crystallography by Das and colleagues showed that the TPR sequence motif was composed of a pair of antiparallel alpha helices.

[1] [3] In terms of sequence, a TPR possesses a mixture of small and large hydrophobic residues, nonetheless, no positions are fully invariant.

[5] Neutrophil cytosolic factor 2 is an essential to NADPH oxidase complex which in turn produces superoxides in response to microbial infection.