Roxana, sometimes spelled Roxanna, is a neighborhood in southwestern East Chicago, Indiana, south of the Grand Calumet River and north of Michigan Street.

It is the only East Chicago neighborhood located south of the Grand Calumet.

[1] The neighborhood is traversed by the Indiana Toll Road and by the South Shore Line passenger railroad, which stops in Roxana at the East Chicago station.

[3] A pipeline carried sulfuric acid from the Grasselli Chemical plant to the refinery.

[4] The restoration of the Roxana Marsh, which was completed in 2013, involved the removal of six hundred thousand cubic yards of sediment contaminated with PCBs, PAHs, heavy metals, and other contaminants.