Mehran was born in Tehran, Iran, before coming to the United States.

from St. George's University School of Medicine in Grenada, West Indies in 1987.

[8] In 2019, she was honored as the Mount Sinai Professor in Cardiovascular Clinical Research and Outcomes.

[9] Mehran advocates for women in medicine with a focus on her field of cardiology, including a study in The Lancet that showed a lack of gender-specific research related to women's heart health.

[12] She was a founding physician of the Cardiovascular Research Foundation, New York City, in 2000.