In 1998, she also played opposite Isabelle Huppert in The School of Flesh (L'École de la Chair) by Benoît Jacquot.

A few years later, she crossed paths with the renowned director who would make her well-known and, according to Roxane, who made her learn her craft: Catherine Breillat.

In 2006, Mesquida played alongside Vincent Cassel in Sheitan, by Kim Chapiron, after which she decided to move to the United States.

[6] From 2011 to 2012, Mesquida played Béatrice, the sister of Louis Grimaldi (Hugo Becker) in the fifth season of the American teen drama television series Gossip Girl.

[18] Following her collaboration with Mr. Oizo and Justice's Gaspard Augé in Rubber, Mesquida started DJing with American rapper MDNA in fashion events.