Many statewide services such as cardiothoracic surgery, neurosurgery, major trauma, high-risk obstetrics, hyperbaric medicine, and neonatal intensive care are based at the hospital, with referrals coming in from the north and northwest.

The main entrance underwent construction for a new underground emergency department.

A more recent hospital redevelopment project was initiated with A$565 million in funding, including a new women's and children's precinct, cancer service, intensive care unit, and day surgery facility.

[4] It serves as a community rehabilitation site, as well as offering allied health and inpatient geriatric services.

In November 1999 the Queen Alexandra wing was leased to become the Hobart Private Hospital.