Scheduled passenger train services between Phnom Penh and Sihanoukville resumed in May 2016 after having been suspended for 14 years.

"A considerable advance was thus taken during the first year and, in 1931, the Company concentrated all her effort on the one hand on the Phnom Penh train station, including embankments, buildings and facilities, which are of an exceptional importance, and secondly on ballast supplies.

Meanwhile, nature, so often hostile in Cambodia, became the main auxiliary against the engineers by packing embankments and consolidating them with vegetation.

Between September 28–30, 1960, twenty-one leaders of the Kampuchean People's Revolutionary Party (KPRP) held a secret congress at the station.

[7] The first important meeting of the Khmer Rouge leadership including Pol Pot was held at the railway station in April 1975, following the fall of Phnom Penh at which the decision to evacuate the cities was taken.