[3][6] According to Forbes magazine, in 1997 Poyiadjis met Lycourgos Kyprianou, a fellow Greek Cypriot with a software company called AremisSoft.

[11] In 2014, Poyiadjis and Martua Sitorus, the co-founder of Wilmar International formed a partnership to create the largest biofuel power plant in Japan.

But due to the Greek and Cypriot economic crisis, the project changed course resulting in a biofuel power plant in Japan.

[18][19][20] In May 2001, the United States Securities and Exchange Commission (SEC) began to investigate AremisSoft after a New York Times article suggested that the company overstated the value of a contract to automate the National Healthcare Service in Bulgaria.

On 19 December 2001, a federal grand jury in the Southern District of New York filed an indictment charging Poyiadjis and Kyprianou with securities fraud in connection with AremisSoft.

In 2005, Poyiadjis voluntarily returned to the United States to plead guilty to one count of conspiracy to commit security fraud.

[24] The case was described in the book Selling America Short, by Richard C. Sauer, which is about the author's time as an Assistant Director with the US Securities and Exchange Commission: "What was supposed to be a quick legal smash and grab [for the SEC] is turning into procedural purgatory.

Poyiadjis has since donated several million dollars to the Department of Physiology and Neuroscience and in support of Dr. Llinas' research studies.

[27] Poyiadjis also provided financial support to the Department of Functional Neurosurgery at the University Hospital at Zurich, where Alkis was treated.