In 1906 Ruben Orbeli became a laws magistr of Saint Petersburg State University's and a laws doctor of Jene University's, also he was author and editor a series of articles in newspaper of Russian treasury department from this moment.

After that he returned to Saint Petersburg State University and worked in branch of USSR Science Academy.

In 1934 on Aleksey Krylov recommendation Ruben Orbeli was invited into the EPRON, while he took up a post of consultant and historian.

Beginning from 1937 to 1939 he organized a series of underwater archeology expeditions to the Black Sea and other water basins.

The during his science activities professor Orbeli created a method of keeping monuments that were risen out of water.