Ruby Skye was a former popular nightclub located at 420 Mason Street in the Tenderloin neighborhood of San Francisco, California, in operation from 1990 to 2017.

The nightclub was housed in the Native Sons of the Golden West building at 420 Mason Street, built in 1912 by architect August Headman.

The system included eight EAW DC1 three-way cabinets, six DCT2 supertweeter arrays and 20 DCS2 subwoofers capable of 140db of bass energy.

[3][4] Ruby Skye played host to a long list of world-renowned DJs, including Above & Beyond, Afrojack, Armin van Buuren, BT, Darude, Deep Dish, John Digweed, Kaskade, Mark Farina, Markus Schulz, Paul Oakenfold, Paul van Dyk, Pete Tong, Roger Sanchez, Sasha, and Tiësto.

[7] A new music venue called August Hall, was opened by new owner Nate Valentine at the same location and would feature a restaurant and a few lanes for bowling on the lower level.