Nomadic tribes of the Shoshone nation used Ruby Valley as a winter home, finding it warmer than nearby locations.
Simpson established a trading post at the south end of Ruby Valley, and George Chorpenning built a way station there for his mail and stagecoach line in 1860.
In September 1862, the U.S. Government established Fort Ruby at the east entrance to the pass to protect the passage of settlers and these important communication connections with residents of California during the war years.
After the American Civil War, John Warren Butterfield and Wells Fargo & Co continued transport service across the West.
Population in the valley has declined, and the lands are principally used in large ranching and farming operations to raise cattle and to grow alfalfa.