The premise of the song is that no matter who is performing at a concert or wherever they go, Run-DMC owns the "house" and always heads the bill.

Run makes references to the trio's influence on hip-hop with the lines "They said rap was crap/But never had this band" and "'Til the ruler came, with a cooler name/Made ya dance and prance and draw the fans insane."

A music video for "Run's House" was filmed in New York City, showcasing the group performing in spots such as the Apollo Theater to a sea of fans.

[2] The hook has also been adapted into the catchphrase of American professional wrestler Swerve Strickland, who presents a call and response to the crowd: When he asks "Whose house?

[3] The Los Angeles Rams also use a variation of the same phrase for their home games, the PA announcer will yell "Whose House?"