The film is a spin-off inspired by David Cross's recurring character Ronnie Dobbs from the HBO sketch comedy series Mr. Show.

Ronnie Dobbs (David Cross)—a redneck petty criminal whose hijinks are caught on tape by a Cops-like television show called Fuzz—is noticed by failing infomercial personality/inventor Terry Twillstein (Bob Odenkirk), who notices Dobbs' popularity with lowbrow viewers.

Many of the regular cast members of Mr. Show made appearances in the film, including Paul F. Tompkins as Safari Guy in TV, Brett Paesel as Infomercial Nancy, Brian Posehn as Tank, Patton Oswalt as Dozer, Sarah Silverman as a Network Executive, Jack Black as Lead Chimney Sweep, Mary Lynn Rajskub as herself, John Ennis as Bartender, Scott Adsit as a Police Negotiator, and Scott Aukerman as a Starving Kidnapper.

In addition to members of Mr. Show, other notable appearances include Dave Foley and Andy Richter as Network Executives, Jeff Garlin as Birthday Woman's Friend, Laura Kightlinger as Birthday Woman, Patrick Warburton as Head of Gay Conspiracy, Doug Benson as Editor #3, David Baddiel and Morwenna Banks as British Couple, and Rhoda Griffis as TV Anchorwoman.

[3] Variety said the film failed "to sustain its initial burst of comic inspiration over the course of its feature-length running time.