The track deals with the subject of infidelity, and is sung from the perspective of a man who declares that he will continue to "run to" his seductive mistress over his faithful partner; critic Ira Robbins for CMJ called it a "cheating classic".

[6] The recording for "Run to You" started on March 27, 1984, at Little Mountain Sound, Vancouver, Canada and continued through the middle of the year.

[6] Adams and Vallance originally wrote the song for Blue Öyster Cult, but the group turned it down.

[9] "Run to You" reached the top 20 on the Canadian singles chart and remained there for seven weeks, peaking at number four.

It held the highest Canadian chart position Adams had attained at the time of release and became his third top-20 single in Canada.

[11][12] Billboard said it was "Full-blast rock" and that "Adams' raspy attack wrestles pop hooks into submission.

"[13] The long instrumental is indicative of the theme of the music video where the protagonist is serenading his guitar as the object of his affection.

After changing their name to En-Rage in some European countries to avoid legal action from the German band, they re-released the single six months later, and this time, it peaked at number three in the UK (eight places higher than the Bryan Adams version) in November 1992.