Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring.
[1] The potential of predicting or estimating individual autozygosity for a subpopulation is the proportion of the autosomal genome above a specified length, termed Froh.
For example, the step-wise reintroduction strategy of the Alpine Ibex in the Swiss Alps created several strong population bottlenecks that reduced the genetic diversity of the newly introduced individuals.
[5] As ROHs smaller than 3 Mb spread throughout the genome are common even in outbred populations,[6] these segments were usually thought to not be important enough to report.
[5] Large ROH can be indicative of uniparental isodisomy[7] with follow-up testing to rule out false positives, there is currently no consistent reporting standards among different laboratories.