[3][4] Spray served as a preceptress and teacher at the Raisin Valley Seminary, Adrian, Michigan, from 1874 to 1877.

[3] After Spray became a resident of Salida, Colorado, she served as president of the Tuesday Evening Club.

During those years, the club built the Salida Public Library, with Spray leading that movement.

She was a member of the Colorado Woman Suffrage Association, the Society of Friends, and the Board of Trustees of the Salida Public Library.

Since 1900, she was an officer of the Colorado State Bureau of Child and Animal Protection, working with marked results in the interest of neglected and abused children.