In 2015, Kihlstedt starred in the NBC miniseries Heroes Reborn, in 2022 in Superman & Lois as Ally Allston, as well as the Fourth Sister in Obi-Wan Kenobi, a role she later voiced in Tales of the Empire in 2024.

In 1995, she appeared in the ABC miniseries Heaven & Hell: North & South, Book III and in 1995 played Lizzie Elmsworth in the BBC adaptation of Edith Wharton's last novel, The Buccaneers.

[6] In 2009, she returned to screen appearing opposite her friend Carla Gugino in the comedy film Women in Trouble, and its sequel, Elektra Luxx.

Kihlstedt guest-starred in a number of television series, including Covert Affairs, Criminal Minds, NCIS, CSI: Crime Scene Investigation, and Drop Dead Diva.

In 2019, she had a recurring role opposite Carla Gugino in her series Jett, and played Kate Laswell in the video game Call of Duty: Modern Warfare.

[6] She is the sister of Oakland-based violinist Carla Kihlstedt, who has been a member of bands such as Charming Hostess, Sleepytime Gorilla Museum, and Tin Hat.