One Mississippi is an American comedy television series created by comedian Tig Notaro and Diablo Cody.

The pilot episode, directed by Nicole Holofcener, aired on Amazon Prime Video on November 5, 2015, and was picked up for a full series after positive feedback from audiences.

Los Angeles radio host Tig Bavaro returns to Bay St. Louis, Mississippi, after receiving news that her mother, Caroline, will be taken off life support following an unexpected fall.

Recovering from both a double mastectomy and a C. difficile infection, Tig moves in temporarily alongside her brother Remy and her stepfather, Bill.

Rotten Tomatoes gives the series a 96% rating based on reviews from 40 critics, with the site's critical consensus stating: "One Mississippi proves an honest vehicle for its moving dramatic narrative, observational comedy, and the genuine acting skills of its lead, Tig Notaro.