Toward the end of the season, Callahan was called up for the third and final time on March 15, 2007, after scoring 35 goals in 60 AHL games, and he would stay with the Rangers through the 2007 Stanley Cup playoffs.

[5] He did not quickly regain his strength at the NHL level, going his next 16 games without a goal, prompting the Rangers to send him back to the Wolf Pack on January 7, 2008.

[13] He then suffered a broken ankle in the team's 79th game of the season against the Boston Bruins after blocking a Zdeno Chára slapshot in the final minutes.

On June 25, five days before free agency was to begin, Callahan signed a six-year contract extension worth an annual average value of $5.8 million to stay with the Lightning.

[20] Just five days after having surgery, however, Callahan returned to the lineup for Game 1 of the Eastern Conference Final against his former team, the Presidents' Trophy-winning New York Rangers.

[22] On October 7, 2015, Lightning head coach Jon Cooper announced that Callahan will wear a permanent "A" as an alternate captain for the 2015–16 NHL season.

[25] On February 22, 2017, Lightning General Manager Steve Yzerman announced that Callahan had a follow-up procedure on his right hip in New York City.

[26] On October 6, 2017, in the 2017–18 season opener against the inner-state rival Florida Panthers, Callahan returned to the Lightning lineup for the first time since undergoing surgery.

[29] On June 20, 2019, it was announced that Callahan was diagnosed with degenerative disc disease and has been placed on long-term injured reserve, effectively ending his professional career.

[31] After spending one year on the Senators' long-term injured reserve list, Callahan officially announced his retirement from the NHL on December 30, 2020.

[32] On January 1, 2010, Callahan was named to the Team USA roster for participation at the 2010 Winter Olympics in Vancouver, with which he earned a silver medal with, falling to Canada in the tournament final.

[35] On September 16, 2016, the Ryan Callahan Foundation announced their new website and that it will begin their mission to provide moments of family unity to those battling pediatric cancer.

The aim of Cally's Crew is to afford patients and families undergoing pediatric cancer treatment the chance to attend a Tampa Bay Lightning home game in the Ryan Callahan Foundation's suite at Amalie Arena.

The "2-4" club functions as a Make-a-Wish style program that provides families with the opportunity to escape cancer treatments with an all-expense-paid trip, experience, or excursion on a monthly basis.

Families undergoing treatment will share their stories via the Ryan Callahan Foundation website in order to promote a community of strength and togetherness.

With respect to the support of local and national charities, the foundation will use monetary funding and also raise awareness for other campaigns to accelerate the timeline towards the elimination of pediatric cancer.