The Denver Broncos selected Clady in the first round of the 2008 NFL draft, and he was named to four Pro Bowls in his eight years with the team.

Clady earned first-team All-Western Athletic Conference (WAC) honors following his sophomore season and was also named to the prestigious SI.com Second-team All-American squad.

Clady was part of Boise State's historic 43–42 overtime win over Oklahoma in the 2007 Fiesta Bowl.

[7] Clady started every game during the 2008 NFL season and gave up just a half of a sack while committing only three penalties.

[8] Following Week 12 of the 2008 NFL season, Peter King of Sports Illustrated said Clady was the third-best rookie overall.

[9] On December 12, 2008, Clady won the Diet Pepsi NFL Rookie of the Week award, after his game against the Kansas City Chiefs.

[10] Clady finished third in voting behind Matt Ryan and Chris Johnson for the 2008 NFL Offensive Rookie of the Year Award.

[13] After the Broncos' October 4, 2009, victory over the Dallas Cowboys, Clady set a new NFL record for consecutive games to start a career without giving up a full sack.

On April 28, 2010, Clady injured his patella tendon while playing basketball but did not miss a game the following season.

[15] In 2011, Clady played all 16 games and was added to the 2012 Pro Bowl roster along with teammate Willis McGahee.

[17] On March 1, 2013, in order to prevent Clady from becoming an unrestricted free agent, the Broncos assigned him the franchise tag, worth $9.823 million.

[citation needed] On September 18, 2013, Clady was placed on season-ending injured reserve, due to a Lisfranc injury he suffered during a week two matchup against the New York Giants.

[20] On February 7, 2016, Clady was part of the Broncos team that won Super Bowl 50 over the Carolina Panthers by a score of 24–10,[21] but he did not play in the game due to his previously torn ACL.

[24] On August 1, 2017, Clady announced his retirement from the NFL after nine seasons, tweeting, "I'm excited about what life holds for me going forward.