Pickett was a consensus All-American selection, named one of the top 25 players in the country by the National Recruiting Advisor and earned All-State honors at Zephyrhills High.

[5] In his rookie season with the Rams, Pickett took a backup role on the defensive front along with playing some special teams.

He started all 16 of the Rams games and racked up a career high 65 tackles (47 solo), which was the highest total for any defensive lineman in the NFL that season.

In 2009, Pickett accepted the new role to the sole nose tackle position with Dom Capers using the new 3-4 defense style.

On February 25, 2010, the Packers applied their Franchise Tag on Pickett, but eventually signed him to a 4-year, $28 million deal on March 12, 2010.

[7][8] In the 2011 season, Pickett continued his role at defensive end while B. J. Raji took over as the sole nose tackle.

The Packers finished the season with a 15–1 record for an NFC North pennant, but lost to the New York Giants by a score of 20–37 in the divisional round.

The Packers clinched another NFC North pennant with an 11–5 record, but lost in the divisional round to the San Francisco 49ers by a score of 31–45.

In response of Louis Nix III going on injured reserve due to knee injuries, Pickett was signed by the Houston Texans on September 24, 2014.

Pickett's primary home is in San Diego, California, and he spends most of his time there when he's not in Green Bay or traveling with the team.

Proceeds are split equally between The American Foundation of Counseling Services of Green Bay and Casa de Amparo in San Diego.

His celebrity guests included Aaron Rodgers, Clay Matthews, Marshall Faulk and Sterling Sharpe among others.