He was influenced by albums like Van Halen and has had many guitar heroes including Brian May from Queen, Steve Stevens, Elliot Easton from The Cars as well as Neil Geraldo from Pat Benatar and Rick Nielsen of Cheap Trick.

Candy were a band featuring original members Kyle Vincent, Jonathan Daniel, John Schubert, and guitarist Geoff Siegel.

Later in the same year, Gilby Clarke replaced Kyle Vincent as lead vocalist, and Roxie joined the lineup on guitar.

The band then moved to New York where they were signed to Atlantic Records at a show opening for Dogs D'amour and Mother Love Bone (some of whose members went on to form Pearl Jam).

In 1997 Roxie joined up with long-time friends drummer Mike Fasano and bassist Will Effertz to create the band Dad's Porno Mag.

The band at various times consisted of the following musicians playing under their GlamNation Aliases, Ryan Roxie ("Peter Kensington), guitars; Eric Singer ("Doyle Harris"), drums and vocals; Eric Dover ("J.C. Jackson"), vocals and guitars; Stefan Adika ("Yashiya"), bass; Derek Sherinian ("Ricky Lemons"), keyboards.

Roxie 77's 11-song debut album, Peace, Love & Armageddon, was released under the small indie Wax-Tone Records label in 2004.

In March 2012 it was announced[4] that Ryan Roxie was rejoining the Alice Cooper band for the forthcoming 2012 tour, joining Tommy Henriksen and Orianthi on guitar, Chuck Garric on bass and Glen Sobel on drums.

Roxie continued touring with Alice Cooper though 2018, and also released two new solo singles the first "Over & Done" in March followed by "To Live and Die in L.A." in May.

December 2018 Ryan Roxie releases the 6th single "Big Rock Show" from "Imagine your Reality" the song guests his bandmates from the current Alice Cooper band Glen Sobel on drums and Tommy Henriksen on bass.

On the day of the single release Ryan had the unique idea to stream a LIVE guitar lesson on how to play the song with help from his friends at PlayAlong Music.

December 31, 2018 Ryan Roxie reforms with GlamNation to perform at Rava Wines in Paso Robles, California with the original GlamNation (2000) line up and special guests Brent Woods, Sebastian Bach, FIFI LaRUE, Jesse Adika, Kenny Lee Lewis, and Brett Scallions.

February 2019 Ryan Roxie is announced as a guest on the 2019 Bandit Rock Awards and performs songs from Imagine Your Reality.

Planet Axe Tour with Brandon Gibbs, Joel Kosche, Robby Miller, and Kenny Bailey in addition to a busy schedule with Alice Cooper on the "Old Black Eyes is Back" 2019 Tour March 2019 Ryan Roxie to appear at the Crow Club in Athens Greece with Alice Cooper tribute band Snakebite, the show is billed as "Ryan Roxie of the Alice Cooper Band meets Snakebite the Alice Cooper Tribute Band" April 2019 Ryan Roxie tours the U.S. with Brandon Gibbs, Joel Kosche, Robby Miller, Kenny Bailey, and Jacob Cade for the Planet Axe 2.0 Tour April 12, 2019 Ryan Roxie releases his 7th single "Look Me In The Eye" from "Imagine your Reality".

April 23, 2019 Ryan Roxie (known for his huge presence on social media) posts his 1000th Facebook post May 2019 Ryan Roxie to again join Alice Cooper on the "Old Black Eyes" Tour through the U.S and Europe beginning on May 4 at the Domination Festival, Mexico and finishing at the Motorpoint Arena Cardiff in the UK on October 12.

May 18, 2019 Ryan Roxie returns to Rava Wines in Paso Robles CA for a special performance with "The Sunset Winos", the all-star band also featured Eric Dover, Stefan Adika, Teddy Andreadis, Johnny Griparic, Jimmy DeGrasso, Slim Jim Phantom, and Paul Black.

September 2019 Ryan Roxie announces he will be joining supergroup Lost Angels for the "Good to the Last Drop UK Tour" for a series of shows beginning on the 17th October in Grimsby with Troy Patrick Farrell, EJ Curse and his old Alice Cooper/Glamnation bandmate Eric Dover.

January 13, 2020, leading into the upcoming 2020 Australian Tour it is announced Ryan Roxie will join Alice Cooper[8] at a fundraising concert at the ANZ Stadium in Sydney, Australia, billed as Fire Fight Australia[9] on the Sunday 16 February 2020 playing alongside multiple international and local acts including other headliners Queen + Adam Lambert, Olivia Newton-John and k.d.

On April 14, 2020, Roxie was interviewed by Metaltalk.net[12] and spoke about, lockdown, guitar lesson, Alice Cooper, Slash, Motely Crue and much more.

On October 16, 2020, Roxie appeared in promotional video testing Aloha by Elk product, the platform essentially lets the user connect over internet and play together like they are in the same room in real time.