He played in Major League Baseball (MLB) for the San Diego Padres and Chicago White Sox.

Liriano played most of the 2011 season in level-A, batting .319 with 12 home runs and 65 stolen bases and was named Midwest League MVP.

Liriano began the 2012 season with the Padres' High-A affiliate Lake Elsinore Storm in the California League and was named a midseason All Star.

[6] On September 4, 2017 his first White Sox hit was a solo home run off Trevor Bauer of the Cleveland Indians.

In 37 games for the Triple–A Colorado Springs Sky Sox, he hit .221/.341/.363 with four home runs, 11 RBI, and five stolen bases.

[9] On January 3, 2019, Liriano signed a minor league contract with the New York Mets that included an invitation to spring training.

On May 29, 2022, Liriano was traded to the Fargo-Moorhead RedHawks of the American Association of Professional Baseball in exchange for a player to be named later.