[3] She appeared in several shows including Darna, Ay, Robot!, Majika, Fantastikids, Fantastic Man,[4] Joaquin Bordado, Buena Familia, and Alyas Robin Hood.

In the year 2016, Cenon starred as Jewel in the romantic gore indie film Ang Manananggal sa Unit 23B.

After winning StarStruck, Cenon appeared as a guest performer on the musical variety show SOP Gigsters (2004 - 2006).

In 2008, Cenon starred in the drama action series Joaquin Bordado alongside Robin Padilla, Iza Calzado, and Mark Herras.

Actresses Jennylyn Mercado and Cristine Reyes were initially tapped to play important roles in the series.

[13] Cenon played a number of supporting roles from 2007 to 2010, Cenon played the superheroine Wena / Fantastic Girl in Fantastic Man (2007) alongside Mark Herras and Jackie Rice, the estranged & cold-blooded Abril Del Castillo in Rosalinda (2009), the jealous and selfish Apple Madrigal in Gumapang Ka sa Lusak (2010), the gold digger Candy / Joy Flores in Langit sa Piling Mo (2010), the happy and lighthearted Darlene Roces in Koreana (2010); and the villain Regine in Bantatay (2010).

The show, which also starred Aljur Abrenica, Bela Padilla, Kris Bernal and the director actress Gina Alajar and is partly based on the 1990s Machete.

Cenon played the ambitious Marla Lucero / Fake Aginaya / New Bugana and soon-to-be a villainess to dancer-actress Bela Padilla's heroine Aginaya/Rosella.

The first drama series is Sana ay Ikaw na Nga where she played the female villain Olga Villavicer / Sandra Sebastian, the psychopathic and cold-hearted murderess.

[17] This romantic gore independent film was directed by Prime Cruz and produced under The IdeaFirst Company.

In December 2016, Cenon together with fellow actors Sunshine Dizon, Gabby Concepcion, and Mike Tan starred in the afternoon primetime series Ika-6 na Utos.

[20][21][22][23][24][25] Cenon was nominated for Best Supporting Actress in the 2017 7th EdukCircle Awards for her performance in Ika 6 na Utos.

Cenon also appeared as the hotel attendant Georgia in the fantasy-comedy film Enteng Kabisote 10 and the Abangers (2016).

Cenon received the Yakushi Pearl Award at Osaka Asian Film Festival 2018 for her performance in Mr. and Mrs.

[33][34] She also appeared as one of the lead cast in The General's Daughter alongside Angel Locsin, Eula Valdez, Maricel Soriano, Janice de Belen, Albert Martinez and Tirso Cruz III.

[37] Cenon, together with LJ Reyes and Chynna Ortaleza, formed a sing-and-dance group called SH3 in January 2010.

[41] Independencia: Ang Panimula, Cenon's first painting exhibit, was held in a restaurant in San Juan City on June 19, 2016.

[46][47][48] In July 2020, Cenon announced on her Instagram that she was five months pregnant with her boyfriend and cinematographer Miguel Antonio Cruz.