From a natural region perspective the Söhre, according to the Handbook of Natural Region Divisions of Germany is a sub-region (357.70) of the Kaufungen Forest and Söhre (357.7) and is home to its highest point, the Hirschberg (643.4 m above sea level (NHN)).

In the eastern north the Söhre transitions into the Southern Kaufungen Forest at the narrow Großalmerode Graben Zone, which follows, in the extreme east the uppermost reaches of the Gelster, in a westerly direction, the Wedemann and, after its confluence, the lower reaches of the Losse.

In the south the Söhre transitions into the Melsungen Upland beyond the valley of the Mülmisch (southwest) and the Landesstraße 3228.

East of the upper reaches of the Losse and outside the nature park, the natural region of the Söhre up to the Hirschberg reaches even greater heights, before descending relatively abruptly to the Hessian-Lichtenau Basin in the southeast and via the Rommerode Hills in the east to the Velmeder Tal, which separates the Kaufungen Forest from the Hoher Meißner, and along which the Laudenbach which flows northwards to the Gelster.

The Großalmerode Graben Zone in the north lies on a narrow muschelkalk nappe.