The principal production plant is located in San Pellegrino Terme in the Province of Bergamo, Lombardy, Italy.

Products are exported to most countries in Europe, the Americas, Oceania and the Middle East, as well as in Asia in Japan, Taiwan, Singapore and Hong Kong.

The springs are located at the foot of a dolomite mountain wall which favours the formation and replenishment of a mineral water basin.

In fact, doctors from Northern Italy in the 13th century used to suggest that their patients go to the Val Brembana spring for treatment.

[13] Over the years, its therapeutic properties attracted many visitors, and, at the beginning of 1900, San Pellegrino Terme became a mineral spa holiday resort with a casino, thermal baths and a hotel.

For this reason, they filed a complaint with the prefect which led Ester Pesenti and Lorenzo Palazzolo to sign an agreement in 1831.

[19] Since the restoration required huge expenses, in 1837, the town leased Pesenti and Palazzolo its share of the water for 12 years.

Since the water had always been connected to the territory, they agreed to give the remaining quarter of the shares to the residents of the town who still can use an external tap free of charge.

When Queen Margherita visited the town in 1905,[22] many articles appeared on the Giornale di San Pellegrino, in which it was illustrated that the bottled mineral water was sold in the main Italian cities, in many cities around Europe, as well as in Cairo, Tangiers, Shanghai, Calcutta, Sydney, Brazil, Peru, and the United States.

At the beginning of the 20th century, carbon dioxide was added to S.Pellegrino to prevent the development of bacteria, especially during long overseas travels.

[23] The spa facilities were renovated, and in 1928, they were equipped with more modern tools for various diagnostic needs, such as the radioscopic and radiograph room and the microscopic and chemical analysis laboratory.

[24] In 1961, Sanpellegrino S.p.A. started to produce bottled mineral water and other beverages in the new San Pellegrino Terme factory.

Today, Sanpellegrino S.p.A. also produces various other flavors of carbonated beverages: Limonata (lemonade), Sanbittèr (bitters), Pompelmo (grapefruit), Aranciata Rossa (blood orange), and Chinò (chinotto).

They were announced through an installation at Eataly's La Scuola Grande in New York where large cans of the new soda flavors were constructed out of flowers.

[34] S.Pellegrino can be seen for the first time in 1949 in the film The Emperor of Capri, directed by Luigi Comencini and since that moment it has appeared in the following movies and TV series.

[12][43] S.Pellegrino is not suitable for infants under 12 weeks of age,[44] because their gastrointestinal tract and urinary system is immature and cannot withstand highly mineralized water.