[1][2][3][4] Clarkson's credits include the series Doctors, Casualty, EastEnders, Footballers' Wives, and Life on Mars, as well as the American series Heroes, House, Dexter, Succession and Ugly Betty.

[5] In 2019, a prequel show to Game of Thrones was announced for HBO with Clarkson attached to direct and executive produce the pilot, in addition to being involved in the creation of the series.

[6][7] The show, reportedly entitled Bloodmoon, took place 5,000 years before the main series and starred Naomi Watts in the lead role.

The pilot had reportedly been shot, but the show was subsequently shelved at HBO in late 2019.

In 2024, Clarkson made her feature directorial debut with the critically panned Madame Web, based on the Marvel Comics character of the same name, and starring Dakota Johnson and Sydney Sweeney.