[3] His father, Sanyasi Raju, was a mrudangam player in the troupe of the renowned violinist, Dwaram Venkataswamy Naidu.

He went on to score music for a number of successful films in multiple languages, including Telugu, Tamil, and Kannada.

He was known for his use of Indian classical ragas and experimentation with foreign musical styles, including Western, Persian, and Arabic influences.

Rajeswara Rao's compositions were known for their classical underpinnings, particularly his use of ragas such as "Mohanam", "Abheri", "Kalyani", and "Sindhu Bhairavi".

He blended Indian classical music with other styles, creating scores that captured a wide range of emotions.