[1] Penicillin is the most common antibiotic used in treatment of S. suis infection; in cases with cardiac involvement (endocarditis), gentamicin should also be given for synergistic effect.

Flies can also spread bacteria between farms and wild boar in many countries are known to carry S. suis and may be an important reservoir.

Many of the patients, and almost all of the fatal cases, had typical symptoms of Streptococcal toxic shock syndrome (STSS).

To date, STSS has only been documented in patients infected with S. pyogenes, another member of the Streptococcus family but very different from S. suis.

[5] The genome of S. suis isolates from the outbreak were examined to see whether its DNA sequence could explain why these particular bacteria were able to cause STSS.

Physicians around the world should be aware of the possibility of S. suis-associated STSS when they see patients with unexplained sepsis who had been in contact with pigs.

[7] The 2012 deaths of 64 of 66 children in Cambodia affected with a complex syndrome including meningitis and pneumonia has been linked to a multiple infection of the children with Dengue fever, Enterovirus 71 and S. suis[8] The use of steroids in the treatment of the severe illness has also been associated with the deaths, and the WHO has advised against the use of steroids in the treatment of this syndrome.

[citation needed] Detection of the zoonotic bacterial pathogen Streptococcus suis was achieved using magnetic glycoparticles.