S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

[7][8] Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma[9] and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.