[5][6] The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.

S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation.

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

This protein is expressed in very restricted regions of the adult brain.

This article on a gene on human chromosome 1 is a stub.