S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

[8] S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.

This article on a gene on human chromosome 1 is a stub.