The SAMe-TT2R2 score[1][2] is a clinical prediction rule to predict the quality of vitamin K antagonist anticoagulation therapy as measured by time in therapeutic INR range (TTR) (VKA e.g.
[3] It has been suggested that it can aid in the medical decision making between VKAs and new oral anticoagulant/non-VKA oral anticoagulant (NOAC e.g. dabigatran, rivaroxaban, apixaban or edoxaban) in patients with atrial fibrillation (AF).
[6] This score reflects the need to offer an improved patient care pathway when using oral anticoagulants.
[8] In a newly diagnosed non-anticoagulated AF patient, the physician may avoid a ‘trial of warfarin’ (which may expose patients to increased stroke risk during the initial inception phase, with suboptimal anticoagulation control[9]) and make an informed decision between patients likely to do well on a VKA (SAMe-TT2R2 score 0–2) or where a VKA is perhaps likely to be associated with poor quality anticoagulation control.
Using the above table add together points assigned for different factors to a maximum score of 8.