SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes.

Since then, a number of associations between skin conditions and osteoarticular disorders have been reported under a variety of names, including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy.

The term SAPHO (an acronym for synovitis, arthritis, pustulosis, hyperostosis, osteitis) was coined in 1987[3] to represent this spectrum of inflammatory bone disorders that may or may not be associated with dermatologic pathology.

[citation needed] In children, the SAPHO syndrome is most likely to affect the metaphysis of long bones in the legs (tibia, femur, fibula), followed by clavicles and spine.

[4][5][6] Treatment with tumor necrosis factor alpha antagonists (TNF inhibitors) has been tried in a few patients with limited success.