[5][6][7] The semaphorins are a family of proteins that are involved in signaling.

All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993).

Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168).

SEMA3F is a secreted member of the semaphorin III family.

[supplied by OMIM][7] This article on a gene on human chromosome 3 is a stub.