Continuing eastbound, Route 60 encounters the intersection of 22nd Street which leads to Allegheny Regional Railroad Station on the Manayunk/Norristown Line.

Both the Manayunk/Norristown and the Chestnut Hill West Line cross over Allegheny Avenue and Route 60 at the northeast corner of 21st Street.

After the two bridges, it enters the Allegheny West neighborhood, skipping past 20th and 19th Streets, before passing under the Lansdale/Doylestown Line between North Broad and Wayne Junction stations.

[1] This discontinuity of Route 60 between 17th and 21st Streets existed in order to avoid crossing three different railroad lines at grade between those streets that were present when the trolley line was first established in 1906: the Reading Railroad's Ninth Street Branch (now part of SEPTA's Main Line), the Chestnut Hill Branch of the Pennsylvania Railroad, and the Reading's Norristown Branch, in westward succession, all featuring extremely heavy passenger traffic.

In that year, trolley tracks were finally installed between 17th and 21st as the Reading completed a project grade-separating the branch (now SEPTA's Manayunk/Norristown Line) over Allegheny, 21st and 22nd Streets through the neighborhood.

On February 24 of that year, a loop was constructed at 35th and Allegheny,[3] and the line's eastern terminus was soon changed from the Richmond & Allegheny crossover to the adjacent Richmond & Westmoreland loop used by Route 15, thus allowing Route 60 to be assigned PCC cars cascaded from Callowhill Depot.

A shortage of operable trolley cars had plagued SEPTA since a disastrous fire at the Woodland Depot in fall 1975; although 30 used PCCs from Toronto, Ontario were subsequently purchased (and used on routes such as the 60), some of these cars had major end-of-life issues, while SEPTA's maintenance of its existing trolley fleet remained abysmal.

Route 60 remained physically intact until a 1983 water main replacement near the intersection of Kensington and Allegheny Avenues required the removal of track; the Philadelphia Water Department was told by SEPTA management that the trackage would not be used again, and thus did not replace it.