[1] Charities that use the SERV name operate across England: Their volunteers work outside normal office hours and use either their own or the charity's dedicated response motorcycles to transport items such as blood for transfusion, blood samples for pathological or microbiological analysis, drugs, patient notes, x-rays, scans, medical equipment, samples, vaccines and donated human breast milk.

Some of the SERV groups were founder members of the Nationwide Association of Blood Bikes (NABB).

[2] Similarly to the motorcycles, all vehicles are bought and run purely on donations.

[citation needed] SERV charities often resupply regional air ambulances with blood products on a 24/7, 365 basis.

This does involve volunteers going out and performing restock runs on Christmas Day.