2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N643001158194ENSG00000147010ENSMUSG00000040990Q96B97Q5JPT2Q8R550NM_001353892NM_001353893NM_001353894NM_001353895NM_001353897NM_001374701NP_001340821NP_001340822NP_001340823NP_001340824NP_001340826NP_001361630SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85[5], in rodents - Ruk[6]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.

[7][8] CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins.

The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).

[supplied by OMIM][9] SH3KBP1 has been shown to interact with B-cell linker,[10] Grb2,[11][12] SH3GLB2,[13][14] SH3GL3,[13] SH3GL2,[14] BCAR1,[10] Epidermal growth factor receptor,[14][15] CBLB,[15] Cbl gene,[10][12][13][14][15] SOS1,[10] CRK[10] and PAK2.

[16]