5763059009ENSG00000154447ENSMUSG00000031642Q7Z6J0Q69ZI1NM_020870NM_021506NM_198678NP_065921NP_067481Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.

[5][6] This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac.

Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network.

The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.

This article on a gene on human chromosome 4 is a stub.