The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin.
Evidence shows that these proteins play key roles in the mineralization of these tissues.
[1] The following are categorized as SIBLING proteins:[1][2] The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.
[3]