9990107723ENSG00000140199ENSMUSG00000027130Q9UHW9Q924N4NM_133647NM_001365088NM_133648NM_133649NM_001362700NP_598408NP_001352017NP_598409NP_598410NP_001349629Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.

K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential.

The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions.

Alternate splicing results in multiple transcript variants encoding different isoforms, the most important ones being KCC3a and KCC3b.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.