817027411ENSG00000132874ENSMUSG00000024552Q15849Q8R4T9NM_001242692NM_007163NM_001371319NM_001110273NM_001110274NM_030683NM_207651NP_001229621NP_009094NP_001358248NP_001103743NP_001103744NP_109608NP_997534Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.

[5][6] In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism.

Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters.

In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene).

This article incorporates text from the United States National Library of Medicine, which is in the public domain.