11608520521ENSG00000197891ENSMUSG00000061742Q96S37Q8CFZ5NM_001276326NM_001276327NM_144585NM_153378NM_009203NP_001263255NP_001263256NP_653186NP_700357NP_033229Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

[5] Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys.

[9] Lesinurad, Ruzinurad, Verinurad, Epaminurad, Lingdolinurad, Xininurad, Puliginurad and dotinurad are urate transporter inhibitors that have been approved to treat gout.

[10][11] Lesinurad enhances urate excretion by inhibition the tubular re-absorption.

[12][13] This article incorporates text from the United States National Library of Medicine, which is in the public domain.