It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues.

[6] The protein encoded by this gene is a transmembrane glycoprotein that functions as a sulfate transporter.

It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells, and is instrumental in chloride reuptake, aiding in the creation of an osmotic gradient for resorption of fluid from the lumen of the intestine.

[7] Mutations in this gene have been associated with congenital chloride diarrhoea,[5] a treatable disease.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.