It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1).

It is believed[5] to interact via long-range allostery, involving significant protein dynamics.

The ERM proteins, together with merlin, the NF2 (MIM 607379) gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro.

Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger (SLC9A3; MIM 182307).

[supplied by OMIM][6] Sodium-hydrogen antiporter 3 regulator 1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.